[HTML][HTML] Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ …
M Waldeck-Weiermair, C Jean-Quartier, R Rost… - Journal of Biological …, 2011 - ASBMB
Cytosolic Ca 2+ signals are transferred into mitochondria over a huge concentration range.
In our recent work we described uncoupling proteins 2 and 3 (UCP2/3) to be fundamental for
mitochondrial uptake of high Ca 2+ domains in mitochondria-ER junctions. On the other
hand, the leucine zipper EF hand-containing transmembrane protein 1 (Letm1) was
identified as a mitochondrial Ca 2+/H+ antiporter that achieved mitochondrial Ca 2+
sequestration at small Ca 2+ increases. Thus, the contributions of Letm1 and UCP2/3 to …
In our recent work we described uncoupling proteins 2 and 3 (UCP2/3) to be fundamental for
mitochondrial uptake of high Ca 2+ domains in mitochondria-ER junctions. On the other
hand, the leucine zipper EF hand-containing transmembrane protein 1 (Letm1) was
identified as a mitochondrial Ca 2+/H+ antiporter that achieved mitochondrial Ca 2+
sequestration at small Ca 2+ increases. Thus, the contributions of Letm1 and UCP2/3 to …
