The role of the leucine zipper in the fos–jun interaction
T Kouzarides, E Ziff - Nature, 1988 - nature.com
T Kouzarides, E Ziff
Nature, 1988•nature.comMutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine
residues stabilizes the interaction between the fos and jun proteins. We show that the
complex between fos and jun can bind to DNA more tightly than either protein alone and that
basic residues adjacent to the leucine repeat offos contribute to the DNA-binding potential of
the complex.
residues stabilizes the interaction between the fos and jun proteins. We show that the
complex between fos and jun can bind to DNA more tightly than either protein alone and that
basic residues adjacent to the leucine repeat offos contribute to the DNA-binding potential of
the complex.
Abstract
Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine residues stabilizes the interaction between the fos and jun proteins. We show that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat offos contribute to the DNA-binding potential of the complex.
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