[HTML][HTML] Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein
P Kaspar, M Dvoráková, J Králová, P Pajer… - Journal of Biological …, 1999 - ASBMB
Using the yeast two-hybrid system, the transcription factor ATBF1 was identified as v-Myb-
and c-Myb-binding protein. Deletion mutagenesis revealed amino acids 2484–2520 in
human ATBF1 and 279–300 in v-Myb as regions required for in vitro binding of both
proteins. Further experiments identified leucines Leu 325 and Leu 332 of the Myb leucine
zipper motif as additional amino acid residues important for efficient ATBF1-Myb interaction
in vitro. In co-transfection experiments, the full-length ATBF1 was found to form in vivo …
and c-Myb-binding protein. Deletion mutagenesis revealed amino acids 2484–2520 in
human ATBF1 and 279–300 in v-Myb as regions required for in vitro binding of both
proteins. Further experiments identified leucines Leu 325 and Leu 332 of the Myb leucine
zipper motif as additional amino acid residues important for efficient ATBF1-Myb interaction
in vitro. In co-transfection experiments, the full-length ATBF1 was found to form in vivo …
