PYHIN proteins and HPV: Role in the pathogenesis of head and neck squamous cell carcinoma
Microorganisms, 2019•mdpi.com
In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of
head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role
of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible
protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation
to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2
expression depends on HPV infection in HNSCC. They represent viral restriction factors and …
head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role
of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible
protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation
to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2
expression depends on HPV infection in HNSCC. They represent viral restriction factors and …
In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2 expression depends on HPV infection in HNSCC. They represent viral restriction factors and are key components of the intrinsic immunity activated against different viruses, including HPV. This review analyzed and summarized the recent findings about the role of PYHIN proteins in HPV+ and HPV− HNSCC.
MDPI