Chemoproteomic analysis of intertissue and interspecies isoform diversity of AMP-activated protein kinase (AMPK)
J Wu, D Puppala, X Feng, M Monetti… - Journal of Biological …, 2013 - ASBMB
AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that senses and governs
changes in the cellular energy balance represented by concentrations of AMP, ADP, and
ATP. Each of its three chains (α, β, and γ) exists as either two or three subtypes, theoretically
allowing up to 12 different forms of the complete enzyme. Tissue specificity in the distribution
of AMPK subtypes is believed to underpin a range of biological functions for AMPK, a central
regulator of metabolic function and response. It is of particular interest for drug discovery …
changes in the cellular energy balance represented by concentrations of AMP, ADP, and
ATP. Each of its three chains (α, β, and γ) exists as either two or three subtypes, theoretically
allowing up to 12 different forms of the complete enzyme. Tissue specificity in the distribution
of AMPK subtypes is believed to underpin a range of biological functions for AMPK, a central
regulator of metabolic function and response. It is of particular interest for drug discovery …
