[HTML][HTML] Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice
M Han, T Ishikawa, CC Stroupe, HA Breckenridge… - Mucosal …, 2021 - Elsevier
Compared to other RV species, RV-C has been associated with more severe respiratory
illness and is more likely to occur in children with a history of asthma or who develop
asthma. We therefore inoculated 6-day-old mice with sham, RV-A1B, or RV-C15.
Inflammasome priming and activation were assessed, and selected mice treated with
recombinant IL-1β. Compared to RV-A1B infection, RV-C15 infection induced an
exaggerated asthma phenotype, with increased mRNA expression of Il5, Il13, Il25, Il33 …
illness and is more likely to occur in children with a history of asthma or who develop
asthma. We therefore inoculated 6-day-old mice with sham, RV-A1B, or RV-C15.
Inflammasome priming and activation were assessed, and selected mice treated with
recombinant IL-1β. Compared to RV-A1B infection, RV-C15 infection induced an
exaggerated asthma phenotype, with increased mRNA expression of Il5, Il13, Il25, Il33 …
