Skn-1a (Pou2f3) specifies taste receptor cell lineage
I Matsumoto, M Ohmoto, M Narukawa… - Nature …, 2011 - nature.com
I Matsumoto, M Ohmoto, M Narukawa, Y Yoshihara, K Abe
Nature neuroscience, 2011•nature.comFunctional diversification of taste cells is crucial for proper discrimination of taste qualities.
We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and
bitter taste cells. Skn-1a–deficient mice lacked electrophysiological and behavioral
responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet,
umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for
generating and balancing the diverse composition of taste cells.
We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and
bitter taste cells. Skn-1a–deficient mice lacked electrophysiological and behavioral
responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet,
umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for
generating and balancing the diverse composition of taste cells.
Abstract
Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a–deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells.
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