Early-life heterologous rhinovirus infections induce an exaggerated asthma-like phenotype
Background Early-life wheezing-associated respiratory tract infection by rhinovirus (RV) is a
risk factor for asthma development. Infants are infected with many different RV strains per
year. Objective We previously showed that RV infection of 6-day-old BALB/c mice induces a
mucous metaplasia phenotype that is dependent on type 2 innate lymphoid cells (ILC2s).
We hypothesized that early-life RV infection alters the response to subsequent heterologous
infection, inducing an exaggerated asthma-like phenotype. Methods Wild-type BALB/c mice …
risk factor for asthma development. Infants are infected with many different RV strains per
year. Objective We previously showed that RV infection of 6-day-old BALB/c mice induces a
mucous metaplasia phenotype that is dependent on type 2 innate lymphoid cells (ILC2s).
We hypothesized that early-life RV infection alters the response to subsequent heterologous
infection, inducing an exaggerated asthma-like phenotype. Methods Wild-type BALB/c mice …